Ponente
Descripción
X-ray fluorescence imaging (XFI) is an emerging molecular imaging technique that combines high sensitivity with high spatial resolution, offering significant penetration depth in tissues while minimizing ionizing radiation exposure compared to current methods. This makes XFI a promising tool for early cancer detection and personalized treatment. The “Integrated Molecular Imaging for Personalized Biomarker-based Breast Cancer Characterization and Treatment (IMMPRINT)” project aims to develop a proof-of-principle (POP) demonstrator that leverages X-ray fluorescence computed tomography (XFCT) as a novel hybrid modality for tumor profiling, with a focus on breast cancer (BC). Within IMMPRINT, specifically engineered and targeted nanoparticles, such as gold nanoparticles (GNPs), will be employed to identify distinct signatures of intra and inter – tumor heterogeneity in BC. The sensors chosen for the POP are the pnCCD sensors produced by MPI HLL in Munich. To support system development, Monte Carlo simulations are being performed on a tumor – bearing mouse model loaded with GNPs, using the GEANT4 simulation toolkit. Fluorescence photons are generated when GNPs are excited by incident X-rays and detected with a silicon detector. Simulation results that outline critical parameters for detector development and system design will be presented.
