se-fis-med: Feasibility study of clinical target volume definition for soft-tissue sarcoma using diffusion tensor imaging

por Dr. Nadya Shusharina (Massachusetts General Hospital)

lunes 11 abr. 2022 16:00 → 17:00 Europe/Madrid

Medical Physics Seminar - Seminario de Física Médica

Title: Feasibility study of clinical target volume definition for soft-tissue sarcoma using diffusion tensor imaging

Author: Nadya Shusharina, PhD

Affiliation: Massachusetts General Hospital.

Summary: We explore usability of the diffusion tensor MRI (DT-MRI) for defining the boundary of the clinical target volume in muscle tissue. Eight healthy volunteers were recruited to acquire MR images of the left and right thigh. The imaging session consisted of (a) two high resolution anatomical MRI scans (spin-echo, SE), T1- and T2-weighted; (b) a diffusion weighted (DW) spin-echo-based scan using an echo planar acquisition with fat suppression. The thigh muscles were auto segmented using CNN. DT-MRI data was used as a geometry encoding input to solve the anisotropic Eikonal equation with Hamiltonian Fast-Marching method. The iso-levels of the solution modeled the CTV boundary. The auto-segmented muscles of the thigh agreed with manually delineated with the Dice score ranging from 0.8 to 0.94 for different muscles. The directional noise of the DT data as an angle of deviation from the average direction ranged from 31° to 40°. Anisotropy of the iso-levels was compared across muscles with different anatomical orientation within the thigh, between muscles in left and right thighs of each subject and between muscles of different subjects. Analysis showed a high degree of consistency across all comparisons.

 

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