Speaker
Abstract
In PET-based beam range verification for particle therapy, new measurements and evaluations of the reaction cross-sections producing β+ emitters are required in order to compare the measured and simulated activity distribution in the patient.
We have conducted a comprehensive experimental campaign at several facilities using different ion beams in the therapeutic energy range and different PET imaging technologies to detect short-lived (online PET monitoring) and long-lived (offline PET monitoring) radionuclides. The following experimental data will be presented:
a) The proton-induced production of the long-lived 11C (t1/2=20 min), 13N (t1/2=9.9 min) and 15O (t1/2=2 min) isotopes produced in the main elements of the human body (C, N and O), measured at the Spanish National Center of Accelerators (CNA) up to 20 MeV, and at the West German Proton Therapy Center (WPE) from 30 up to 200 MeV.
b) The proton-induced cross-sections of the short-lived 12N (t1/2=11 ms) in C, 38mK (t1/2=0.92 s) in Ca and 29P (t1/2=4 s) in P up to 200 MeV and the carbon-induced cross-sections of 12N and 10C (t1/2=19 s) in C up to 400 MeV/u, measured at the Heidelberg Ion-Beam Therapy Center (HIT).
The relevance of the new data and future work to improve PET range verification will be discussed.