Moderadores
Transferencia de Tecnología
- Gabriela Llosa (IFIC-CSIC)
- Mª Carmen Jiménez-Ramos (Centro Nacional de Aceleradores-Sevilla)
Transferencia de Tecnología
- Gabriela Llosa (IFIC-CSIC)
- Mª Carmen Jiménez-Ramos (Centro Nacional de Aceleradores-Sevilla)
Transferencia de Tecnología
- Mª Carmen Jiménez-Ramos (Centro Nacional de Aceleradores-Sevilla)
- Gabriela Llosa (IFIC-CSIC)
In recent years, FLASH radiotherapy has gained attention as a promising approach to reduce damage to healthy tissues while maintaining effective tumor control. To meet the requirements for FLASH, ultra-intense pulsed beams—dose rates exceeding 40 Gy/s—must be achieved. This has created the need to develop facilities capable of conducting experiments at sufficiently high rates as well as...
Purpose: The dose per fraction, the dose rate and the delivery time in radiation therapy are key parameters to understand both the efficacy of the treatment and the level of radiation toxicity in normal tissue. Laser-driven sources are known for their brightness and short pulse duration, and these characteristics offer the possibility to study the biological effects of pulsed radiation beams...
Proton therapy uses protons with energies ranging from a few MeV to over 250 MeV to treat cancer. The interactions of these protons with tissues or materials generate secondary neutrons that pose a risk of irradiation. The dosimetry of these neutrons must be measured accurately, and it must be monitored to minimize the risk of apparition of secondary cancers in patients, and also to protect...
Radiochromic films (RCFs) have been widely used for dosimetry in photon, electron, and proton radiation therapy due to their tissue-equivalent response and high spatial resolution. However, when used with proton beams, especially at energies below 20 MeV, RCFs exhibit dose underestimation, a phenomenon known as LET quenching. This underestimation necessitates the application of a Relative...
This study consists of a proof-of-concept based on the use of CEPA4 scintillator [1, 2] of IEM pCT scanner [3, 4] to verify the range of a proton beam at energies relevant for proton therapy performed at Centrum Cyklotronowe Bronowice (Krakow, Poland). The aim of this work is to test the sensitivity of proton range verification method based on the detection of gamma radiation in vivo resulting...
The PoliTech-1 mission consists of a nanosatellite that includes various payloads, among which is the LEON system (Low Earth Orbit compact Neutron detector). Its primary scientific objective is to measure the temporal dynamics of the low-energy neutron terrestrial albedo, depending on the solar activity level, time, and the satellite's spatial coordinates. The measurements will enable the...
Proton therapy requires precise knowledge of the patient anatomy to ensure an accurate dose delivery [1]. X-ray computed tomography (CT) images are used nowadays to calculate the relative stopping power (RSP) needed for proton therapy treatment planning [2]. Recent studies indicate that tomographic imaging using protons has the potential to provide a more accurate and direct measurement of RSP...
Purpose
FLASH radiotherapy is a promising technique in radiotherapy, where ultra-high dose rates (>40 Gy/s) have been shown in in-vitro and animal studies to have a protective effect on healthy tissues, while maintaining the same efficacy in treating tumors as conventional radiotherapy. We performed a survival and viability assay with an X-ray beam at FLASH and conventional dose rates,...
Boron Neutron Capture Therapy (BNCT) is an experimental form of radiotherapy that uses boron, injected to the patient within a target molecule that accumulates selectively in cancerous cells. This therapy exploits the large neutron capture cross-section of boron to deliver a targeted dose from neutron irradiation. BNCT has shown great promise with the advent of accelerator-based technologies,...
Hadron therapy offers advantages over conventional radiotherapy due to the maximization of the dose at the Bragg peak. However, further advantages could be obtained if a quasi-real-time monitoring system for ion-range verification would be available. In particular, this would help to reduce safety margins and enhance its potential benefits, due to various sources of systematic uncertainty. Two...
In recent years, there has been a growing interest in laser-driven ion accelerators as a potential alternative to conventional accelerators [1]. A particularly promising application is the production of radionuclides relevant for medical diagnosis, such as 11C for PET imaging. Typically, the production of these nuclides is centralised at cyclotrons, reducing the number of facilities required,...
Compton gamma cameras have been developed in recent years to image radionuclides across various nuclear application fields. A crucial aspect of nuclear medicine is the precise localization of radioisotopes to guide interventional procedures. In this context, Compton gamma cameras offer higher sensitivity than conventional pinhole gamma cameras, as they do not require mechanical collimation....
The Leksell Gamma Knife (LGK) is a non-invasive stereotactic radiosurgery device used to treat brain tumors and functional disorders. It delivers highly precise gamma radiation from 192 high-activity cobalt-60 sources. Each sector of the Leksell Gamma Knife Perfexion (PFX) contains 24 cobalt-60 sources and can move independently between five different positions. Three of these positions...
The IRIS group at IFIC (Valencia, Spain) continues the development of Compton cameras and their application to radionuclide therapy with successful results.
The previous prototype, MACACO III, was composed of three detector planes. Each plane features one LaBr3 crystal of size 25.8 mm x 25.8 mm x 5 mm, coupled to a SiPM array. The system was initially tested with phantoms filled with FDG and...
