se-fis-med: Dosimetry in radiobiology and the impact of dosimetric reporting and standardization on study reproducibility

por Prof. Emily Draeger (Yale School of Medicine)

lunes 16 oct. 2023 16:00 → 17:00 Europe/Madrid

1001-Primera-1-1-1 - Paterna. Seminario (Universe)

Medical Physics Seminar - Seminario de Física Médica

Title: Dosimetry in radiobiology and the impact of dosimetric reporting and standardization on study reproducibility

Author: Emily Draeger, PhD

Affiliation: Yale School of Medicine

Summary:

Reproducibility within radiobiology has been recognized as an important issue within the field. If research is difficult to interpret or reproduce, it can complicate translation of preclinical work into clinical practice. One component that is crucial for study interpretation and reproducibility is the accurate reporting of experimental methods, including details of how biological samples are irradiated. Because biological effects induced by radiation damage exhibit very steep dose-response curves, any uncertainties or inconsistencies in dose delivery can lead to significant differences in biological effect. Dosimetric parameters are well understood and can be accurately described, and therefore it is important to understand which parameters need to be reported to completely describe an irradiation protocol. Proper reporting of these parameters is crucial for reducing uncertainties in observed biological effects, and standardizing the reporting of these parameters can lead to more reproducible experimental conditions. In this presentation, I will discuss how uncertainties in dosimetric parameters can affect dose delivery, explain which parameters are needed to fully describe an irradiation protocol, and introduce why standardization of dosimetric reporting is difficult, but very important, in radiobiology.

Online link: https://conectaha.csic.es/b/fer-gny-a0x-omp. The room access code will be sent per e-mail.