Many theories beyond the standard model (BSM) contain new CP-odd and CP-even neutral scalars, along with new vector-like fermions (VLF). We construct many general models, where the VLFs are present along with the two Higgs doublet model (2HDM), with the new fermions in singlet and doublet representations of the SU(2). We present the heavy scalar phenomenology to show how the presence of VLFs in the theory can modify the LHC observables. Then we study a simple little Higgs model where the 2HDM+ VLF structure is present, to explore the effects of VLFs on the heavy scalar phenomenology of that model. We present our results taking into account the effects of VLFs on the light (125 GeV) Higgs, with the modifications being consistent with the LHC results.