Though the observed CMB is at very low energy, it encodes ultra high-energy physics in spatial variations of the photon temperature and polarization fluctuations. This effect is believed to be dominated by the initial quantum state of the Universe. �I will describe the first theoretical tools by which to construct such a state from fundamental physics. �There are three specific observational effects this initial state will produce: a ringing signal in the power spectrum of quantum field fluctuations, enfolded type of non-Gaussian fluctuations, and a calculable primordial gravitational wave background. �We will soon be able to compare these predictions against experiment, allowing one to rule out classes of quantum gravity models. Now is the critical time to undertake such investigations, with a number of ongoing and planned experiments such as WMAP, Planck, and CMBPol poised to collect a wealth of precision data.