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SUMMARY:se-fis-med: Benefits of range uncertainty reductions in proton the
 rapy and interplay with proton arc therapy implementation
DTSTART;VALUE=DATE-TIME:20231218T160000Z
DTEND;VALUE=DATE-TIME:20231218T170000Z
DTSTAMP;VALUE=DATE-TIME:20260312T224147Z
UID:indico-event-7271@indico.ific.uv.es
DESCRIPTION:Medical Physics Seminar - Seminario de Física Médica\n\nTitl
 e: Benefits of range uncertainty reductions in proton therapy and interpla
 y with proton arc therapy implementation\n\nAuthor: Sebastian Tattenberg\,
  PhD\n\nAffiliation: TRIUMF\, Vancouver\, BC\, Canada and Northern Ontario
  School of Medicine (NOSM) University\, Sudbury\, ON\, Canada\n\nSUMMARY: 
 \n\nMotivation: Conventional external beam radiotherapy for cancer is gene
 rally photon-based\, but due to higher dose conformality to the tumor\, pr
 oton therapy treatments have experienced rapidly-growing interest. However
 \, uncertainties in the in vivo proton range remain a considerable hurdle.
 \n\nMethods: Based on a total of 25 patients with tumors in the brain or t
 he head & neck region\, the benefits of a range uncertainty reduction from
  the current clinical level of approximately 3.5% to a potentially achieva
 ble level of 1% were quantified. In addition\, proton arc therapy (PAT) tr
 eatment plans utilizing a much higher number of irradiation directions (72
  rather than 4) were created for a sub-set of five patients. The benefit o
 f PAT implementation was then determined and compared to range uncertainty
  reduction benefits prior or subsequently to PAT implementation.  \n\nRes
 ults: A 3.5% to 1% range uncertainty reduction reduced evaluated normal ti
 ssue complication probabilities (NTCPs) by up to 3.2 percentage points (pp
 ). The benefits of novel proton beam arrangements which only become feasib
 le as range uncertainties are reduced often exceeded the direct benefits o
 f range uncertainty reductions. In the five patient sub-set\, the mean NTC
 P reduction achieved via PAT implementation (2.5 pp) was four times higher
  than the mean benefit of a 3.5% to 1% range uncertainty reduction (0.6 pp
 ). PAT implementation did not\, however\, reduce the benefits associated w
 ith reducing proton range uncertainties.\n\nConclusion: Proton range uncer
 tainty reductions were associated with considerable dosimetric benefits\, 
 parts of which resulted from the feasibility of novel beam arrangements at
  lower range uncertainties. The benefits of PAT implementation exceeded th
 e benefits of a 3.5% to 1% range uncertainty reduction significantly. Howe
 ver\, PAT implementation did not reduce range uncertainty reduction benefi
 ts. Range uncertainty reductions are therefore expected to remain benefici
 al even if achieved subsequently to or in tandem with PAT implementation. 
  \n\nOnline link: https://conectaha.csic.es/b/fer-gny-a0x-omp. The room a
 ccess code will be sent per e-mail.\n\nhttps://indico.ific.uv.es/event/727
 1/
LOCATION:Universe 1001-Primera-1-1-1 - Paterna. Seminario
URL:https://indico.ific.uv.es/event/7271/
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