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SUMMARY:Production of β+ emitters for range verification at the WPE proto
 n therapy centre
DTSTART;VALUE=DATE-TIME:20201214T154500Z
DTEND;VALUE=DATE-TIME:20201214T160000Z
DTSTAMP;VALUE=DATE-TIME:20260517T061115Z
UID:indico-contribution-13889@indico.ific.uv.es
DESCRIPTION:Speakers: Mª Teresa Rodríguez González (Universidad de Sevi
 lla)\nIn proton therapy\, PET range verification requires a comparison of 
 the measured and expected $\\beta^{+}$ activity distributions produced by 
 the beam in the body of the patient by means of nuclear reactions. The acc
 uracy of the expected activity distributions depends on that of the Monte 
 Carlo simulations\, and hence by that of the underlying cross sections dat
 a [1]. These are not available in the full energy range of interest (up to
  230 MeV) and\, when they are\, there are sizable discrepancies between da
 ta sets. Indeed\, several studies confirm the need for more and better mea
 surements and evaluations [2\,3].\n\nIn this work we have measured the pro
 duction yields of the long-lived positron emitters $^{11}$C\, $^{13}$N and
  $^{15}$O in the most abundant elements in the human body (carbon\, nitrog
 en and oxygen) in the full energy range for proton therapy (up to ~230 MeV
 ). The method employed consists in the combination of the multi-foil activ
 ation technique followed by the measurement of the induced activity with a
  clinical PET scanner. The foils used are rich in C\, N and O\, with polye
 thylene layers between them to reduce the beam energy from one foil to the
  next. The method has been successfully used and tested below 18 MeV at CN
 A (Sevilla\, Spain) to obtain the differential cross sections for these re
 actions (paper to be submitted soon).\n\nThe experiment was carried out at
  the West German Proton Therapy Centre (WPE) in Essen (Germany)\, with thr
 ee initial beam energies: 190\, 150 and 100 MeV. The experimental set up a
 nd preliminary results will be presented.\n\n\n[1] Tárkányi et al. J. Ra
 dioanalytical and Nuclear Chemistry. 319 533–666 (2019)\n[2] España et 
 al.\, Phys. Med. Biol. 56(9) 2687-2698 (2011)\n[3] E. Seravalli et al.\, P
 hys. Med. Biol. 57 1659 (2012)\n\nhttps://indico.ific.uv.es/event/5983/con
 tributions/13889/
LOCATION:Virtuales
URL:https://indico.ific.uv.es/event/5983/contributions/13889/
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